In a medium bowl, mix together crab, cream cheese, onion powder, and Worcestershire sauce until well combined.
Heat a skillet over medium heat. Butter one side of one slice of bread. Place the bread - butter side down - in the hot skillet. Top bread with crab mixture; spread filling to edges of bread. Butter one side of a second piece of bread. Place the bread - butter side up - on top of the filling.
Cook until bottom bread slice is golden brown. Carefully flip sandwich, and cook until bread is golden and crispy. Serve warm.
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