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Preheat oven to 350 degrees F. Line baking sheets with parchment paper or Sil-Pat.
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In a medium bowl, combine flour, baking soda, baking powder, and salt.
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In a large bowl, beat together butter, sugar, and brown sugar for 1 to 2 minutes until lightened and fluffy. Add eggs and vanilla; mix until combined and smooth.
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Add flour mixture to butter mixture in two additions. Mix until just combined after each addition.
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Mix in pretzels and white chocolate chips. Stir in sprinkles by hand.
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Drop cookie dough by the tablespoonful onto prepared baking sheets. Bake for 10 minutes or until cookies just being to brown around the edges.